p-(Methylsulphonyl)benzoic acid → HCID 22611202, compound

HRID 1737804Notes

Reaction equation

HRID 1737804 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH3:18][S:19]([C:22]1[CH:30]=[CH:29][C:25]([C:26](O)=[O:27])=[CH:24][CH:23]=1)(=[O:21])=[O:20]>>[CH3:18][S:19]([C:22]1[CH:30]=[CH:29][C:25]([C:26]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:27])=[CH:24][CH:23]=1)(=[O:20])=[O:21]

Participants

3

Reactant 2

HCID 77670p-(Methylsulphonyl)benzoic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611202HCID 22611202, compoundYield 58.3%

Procedure

Beginning with 7.0 mg (0.03 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 18.0 mg (0.09 mMol) 4-(methanesulfonyl)benzoic acid, 7.2 mg of the title compound were recovered.

Sources & evidence

ORD record
ord-bd73230058604fa2baa10113f27e1cc7
Source dataset
uspto-grants-1999_10
Patent number
US05962474

Reaction notes

Loading…