o-Chlorophenylacetic acid → Acetyl chloride, 2-(2-chlorophenyl)-

HRID 1737833Notes

Reaction equation

HRID 1737833 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.S(Cl)([Cl:14])=O>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([Cl:14])=[O:11]

Participants

3

Reactant 2

HCID 17124o-Chlorophenylacetic acidHCID 24386Thionyl Chloride

Product 1

HCID 182669Acetyl chloride, 2-(2-chlorophenyl)-Yield 99%

Procedure

A mixture of 30.0 gm (0.176 mole) of o-chlorophenylacetic acid and 40.0 mL of thionyl chloride was stirred at ambient temperature for 18 hours. The volatiles were then removed in vacuo to give 32.76 gm (99.0%) of o-chlorophenylacetyl chloride as a transparent, pale yellow, mobile liquid.

Workup

  1. customThe volatiles were then removed in vacuo

Sources & evidence

ORD record
ord-81705f54f3794c3aab92742f67326050
Source dataset
uspto-grants-1999_10
Patent number
US05962474

Reaction notes

Loading…