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4-(Imidazol-1-ylmethyl)benzonitrile → 1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-(Imidazol-1-ylmethyl)benzonitrile | HCID 1236449 | — |
| 反応物 | 2-(4-fluorophenyl)acetaldehyde | HCID 11126322 | — |
| 生成物 | 1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole | HCID 21843581 | — |
反応手順
1-[1-(4-cyanophenyl)-3-(4-fluorophenyl)-2-hydroxypropyl]-1H-imidazole is prepared according to the procedure of Example 1 using 1-(4-cyanobenzyl)-imidazole and 4-fluorophenylacetaldehyde as starting materials. The product is purified by flash chromatography.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05962495 |
| 出典データセット | uspto-grants-1999_10 |
| ORD ID | ord-cb0eae4244e0465f9dd3e78820af8ab0 |
| 出典メモ | uspto-grants-1999_10 |