Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(4-Fluorophenyl)-2-propenoic acid → 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(4-Fluorophenyl)-2-propenoic acid | HCID 98070 | — |
| 반응물 | 4-(1,2,4-Triazol-1-ylmethyl)benzonitrile | HCID 7537616 | — |
| 반응물 | Benzenepropanoic acid, 4-fluoro-, ethyl ester | HCID 11816416 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 생성물 | 1-[1-(4-Cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole | HCID 21843580 | — |
반응 단계
1-[1-(4-cyanophenyl)-4-(4-fluorophenyl)-2-oxobutyl]-1,2,4-triazole is prepared according to the procedure described in Example 1 starting from 1-(4-cyanobenzyl)-1,2,4-triazole (1.7 g, 0.0092 mol), n-BuLi (0.0108 mol) and ethyl 3-(4-fluorophenyl)propionate (2.3 g, 0.0117 mol) prepared from 4-fluorocinnamic acid by esterification and hydrogenation. The product is purified by flash chromatography methylene chloride-methanol (95:5) as eluent.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05962495 |
| 출처 데이터셋 | uspto-grants-1999_10 |
| ORD ID | ord-5bdc9d226d0f4139b19173e36e35b09e |
| 출처 메모 | uspto-grants-1999_10 |