Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-ethoxy-1-[[2′-(methoxycarbonyl)[1,1′-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylate | HCID 15654679 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 22596780 | HCID 22596780 | 83% |
Reaction Steps
To a solution of methyl 2-ethoxy-1-[(2'-methoxycarbonylbiphenyl-4-yl)methyl]benzimidazole-7-carboxylate (0.7 g) in methanol (10 ml) was added 1N NaOH (5 ml) and the mixture was stirred at 80° C. for 3 hours. After evaporation of the methanol, the aqueous residue was neutralized with 1N hydrochloric acid to give crystals. The crystals were recrystallized from methanol-chloroform to afford colorless crystals (0.54 g, 83%), m.p. 213-215° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05962491 |
|---|
| Source dataset | uspto-grants-1999_10 |
|---|
| ORD ID | ord-229d0ae2f03c4ce3aa26cfd516f27e9d |
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| Source note | uspto-grants-1999_10 |
|---|
