HRID1737936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID875

2,3-Dihydroxybutanedioic acid

C4H6O6

HCID3283

Diethyl Ether

C4H10O

结构：CN(C)Cc1ccc([C@H]2CC[C@H](OC(=O)Cc3ccc(Cl)cc3)CC2)cc1

HCID178418347

未命名化合物

PRODUCTS

生成物

结构：CN(C)Cc1ccc([C@H]2CC[C@H](OC(=O)Cc3ccc(Cl)cc3)CC2)cc1.O=C([O-])C(O)C(O)C(=O)[O-]

HCID178418492

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

First 0.15 g (0.001 mol) of anhydrous tartaric acid and then 0.39 g (0.001 mol) of trans-O-(4-chlorophenylacetyl)-4-(4-dimethylaminomethylphenyl)-cyclohexanol are dissolved in 7 ml of absolute ethanol. Diethyl ether is then added to the clear solution until it becomes slightly cloudy and it is then left to stand for 8 hours at +4° C. The crystalline product precipitated is suction filtered, washed with diethyl ether and dried. Melting point: 169-171° C. Yield: 0.46 g (86% of theory) C27H34ClNO8 (536.02) Calculated: C 60.50 H 6.39 N 2.61 Cl 6.61 Found: 60.37 6.38 2.65 6.73

WORKUP

后处理

waitit is then left
customThe crystalline product precipitated
filtrationfiltered
washwashed with diethyl ether
customdried

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-55ea716c4e3c44d0a4770bffc28542b2
来源数据集: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05962507
来源说明: uspto-grants-1999_10

反应 SMILES

[C:1]([OH:10])(=[O:9])[CH:2]([CH:4]([C:6]([OH:8])=[O:7])[OH:5])[OH:3].[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:27][CH2:26][C@H:25]([C:28]3[CH:33]=[CH:32][C:31]([CH2:34][N:35]([CH3:37])[CH3:36])=[CH:30][CH:29]=3)[CH2:24][CH2:23]2)=[O:20])=[CH:14][CH:13]=1.C(OCC)C>C(O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([CH2:18][C:19]([O:21][C@H:22]2[CH2:23][CH2:24][C@H:25]([C:28]3[CH:29]=[CH:30][C:31]([CH2:34][N:35]([CH3:36])[CH3:37])=[CH:32][CH:33]=3)[CH2:26][CH2:27]2)=[O:20])=[CH:14][CH:13]=1.[C:6]([CH:4]([CH:2]([C:1]([O-:10])=[O:9])[OH:3])[OH:5])([O-:8])=[O:7]