反应详情

Methyl 5-(dipropylamino)-4-((2-(1,3-dithiol-2-ylidene)-3-methoxy-3-oxopropanoyl)amino)-5-oxopentanoate (5) (111 g) was dissolved in methanol (1 l), followed by the addition of 2.5 N potassium hydroxide solution (300 ml). The resulting mixture was heated under reflux for 2 hours. The solvent was removed under reduced pressure. The resulting residue was washed several times with water, whereby 4-((2-carboxy-2-(1,3-dithiol-2-ylidene)acetyl)amino)-5-(dipropylamino)-5-oxopentanoic acid (6) was obtained as a waxy substance. Without purification, the reaction product was provided for use in the next example.

1. temperatureThe resulting mixture was heated
2. temperatureunder reflux for 2 hours
3. customThe solvent was removed under reduced pressure
4. washThe resulting residue was washed several times with water