反应详情

5.0 g (25 mmol) of 2-aminomethylchroman hydrochloride are dissolved in 50 ml of pyridine; 5.6 g (35 mmol) of cycloheptanecarbonyl chloride are added dropwise to this solution. After 1 hour at 50° C., the mixture is concentrated and the residue is partitioned between water and toluene/ethyl acetate 1:1. The organic phase is filtered over silica gel. The desired product is eluted with toluene/ethyl acetate 5:1. The amide obtained after concentration is further reacted directly.

1. concentrationthe mixture is concentrated
2. customthe residue is partitioned between water and toluene/ethyl acetate 1:1
3. filtrationThe organic phase is filtered over silica gel
4. washThe desired product is eluted with toluene/ethyl acetate 5:1