Ethyl N-(oxomethylidene)valinate → HCID 22611601, compound

HRID 1737986Notes

Reaction equation

HRID 1737986 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[N:18]([CH:21]([CH:27]([CH3:29])[CH3:28])[C:22]([O:24][CH2:25][CH3:26])=[O:23])=[C:19]=[O:20]>>[CH2:25]([O:24][C:22]([CH:21]([NH:18][C:19]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1)=[O:20])[CH:27]([CH3:28])[CH3:29])=[O:23])[CH3:26]

Participants

3

Reactant 2

HCID 2759395Ethyl N-(oxomethylidene)valinateHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611601HCID 22611601, compoundYield 95.3%

Procedure

Beginning with 15.0 mg (0.0655 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 14.56 mg (0.0852 mMol) ethyl 2-isocyanato-3-methylbutyrate, 25.0 mg (95%) of the title compound were recovered.

Sources & evidence

ORD record
ord-0882f30f74174a229a9f3e512b1ac7a4
Source dataset
uspto-grants-1999_10
Patent number
US05962473

Reaction notes

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