HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tryptophol → 5-{4-[2-(Indol-3-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tryptophol | HCID 10685 | — |
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-{4-[2-(Indol-3-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298325 | 16.1% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 5.0 g of 2-(indol-3-yl)-ethanol, 14.4 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 7.73 ml of tributylphosphine, 7.83 g of 1,1'-(azodicarbonyl)dipiperidine and 150 ml of anhydrous benzene were used, to give 3.03 g of the title compound, melting at 81.0-82.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05962470 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-547758c9c0f14ac9acd57b5ca0834941 |
| Source note | uspto-grants-1999_10 |