HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-{4-[2-(7-Azaindol-1-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Reactant | 1H-Pyrrolo[2,3-b]pyridine-1-ethanol | HCID 13285357 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-{4-[2-(7-Azaindol-1-yl)ethoxy]benzyl}-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298299 | 79.5% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 1.77 g of 2-(7-azaindol-1-yl)ethanol (prepared as described in Preparation 18), 4.40 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 2.35 ml of tributylphosphine, 2.39 g of 1,1'-(azodicarbonyl)dipiperidine and 45 ml of anhydrous benzene were used, to give 4.58 g of the title compound, melting at 167.5-168.9° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05962470 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-85a55114aa684f0491428fef2ad5a5a8 |
| Source note | uspto-grants-1999_10 |