HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → 5-[4-(1-Methylindol-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | 1,1'-(Azodicarbonyl)dipiperidine | HCID 73042 | — |
| Reactant | (1-methyl-1H-indol-2-yl)methanol | HCID 295652 | — |
| Reactant | 5-(4-Hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione | HCID 2818126 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 5-[4-(1-Methylindol-2-ylmethoxy)benzyl]-3-triphenylmethylthiazolidine-2,4-dione | HCID 23298332 | 46.6% |
Reaction Steps
A procedure similar to that described in Preparation 4 was repeated, except that 4.30 g of 1-methylindol-2-ylmethanol (prepared as described in Preparation 23), 10.3 g of 5-(4-hydroxybenzyl)-3-triphenylmethylthiazolidine-2,4-dione, 6.65 ml of tributylphosphine, 6.73 g of 1,1'-(azodicarbonyl)dipiperidine and 120 ml of benzene were used, to give 6.28 g of the title compound, melting at 134.3-136.0° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05962470 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-85f037ba787449c797fd1d2b4a5d6d61 |
| Source note | uspto-grants-1999_10 |