3-nitro-N-phenylpyridin-2-amine → 2-N-phenylpyridine-2,3-diamine

Participants

Reaction Steps

A procedure similar to that described in Example 6 was repeated, except that 6.9 g of 3-nitro-2-phenylaminopyridine (prepared as described in Preparation 83) was hydrogenated in a mixture of 150 ml of ethanol and 50 ml of dioxane in the presence of 1.38 g of 10% w/w palladium-on-charcoal. After working up the product as described in Example 6, 4.2 g of the title compound, melting at 137-140° C., were obtained.

Provenance & Evidence