1,2-Dichloroethane → HCID 54108658, compound

Participants

Reaction Steps

To an ice-cooled solution of 5-methyl-3-methylcarbamoyl-hexanoic acid (0.40 g, 2.13 mmol) in dichloromethane (10 ml) was added pentafluorophenol (0.43 g, 2.35 mmol) and EDC (0.45 g, 2.35 mmol). The mixture was stirred at room temperature for 2 h, diluted with more dichloromethane and washed successively with 1 M Na2CO3 solution, 1M HCl and brine. The organic phase was dried (anhydrous MgSO4), filtered and evaporated to leave the title compound as an oil (0.38 g, 56%), which was used in Step D without further purification. 1H-NMR; δ (CDCl3), 5.77 (1H, m), 3.10 (1H, m), 2.83 (3H, d, J=4.7 Hz), 2.75 (2H, m), 1.70 (1H, m), 1.59 (1H, m), 1.31 (1H, m), 0.95 (3H, d, J=4.9 Hz) and 0.93 (3H, d, J=4.8 Hz).

Provenance & Evidence