Water → HCID 21266768, compound

HRID 1738362Notes

Reaction equation

HRID 1738362 reaction equation
[CH3:1][NH:2][NH2:3].[Cl:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12](=O)[CH2:13][C:14](OCC)=[O:15])=[C:7]([F:20])[CH:6]=1.O>C(O)COCCO>[Cl:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([C:12]2[NH:3][N:2]([CH3:1])[C:14](=[O:15])[CH:13]=2)=[C:7]([F:20])[CH:6]=1

Participants

5

Reactant 3

HCID 962WaterHCID 6061MethylhydrazineHCID 15030553HCID 15030553, compound

Product 1

HCID 21266768HCID 21266768, compound

Reagents, catalysts & solvents 1

HCID 8117Diethylene GlycolSolvent

Procedure

34.7 g (0.75 mol) of methylhydrazine were added to a solution of 177 g (0.68 mol) of ethyl 3-(4-chloro-2-fluoro-5-methylphenyl)-3-oxopropionate in 500 ml of diethylene glycol. After 6 hours at 100° C., the mixture was poured into 4 l of water. The solids were subsequently separated off and dried. Yield: 133 g; m.p.: 155-156° C.

Workup

  1. customThe solids were subsequently separated off
  2. customdried

Sources & evidence

ORD record
ord-7b12befd73de497e9d5cf722f758230c
Source dataset
uspto-grants-1999_10
Patent number
US05962694

Reaction notes

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