Thiophene-3-sulfonyl Chloride → N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide

HRID 1738405Notes

Reaction equation

HRID 1738405 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([S:6](Cl)(=[O:8])=[O:7])=[CH:2]1.[NH2:10][C:11]1[O:15][N:14]=[C:13]([CH3:16])[C:12]=1[Br:17]>>[Br:17][C:12]1[C:13]([CH3:16])=[N:14][O:15][C:11]=1[NH:10][S:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)(=[O:8])=[O:7]

Participants

3

Reactant 2

HCID 2776378Thiophene-3-sulfonyl ChlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

Product 1

HCID 12146375N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamideYield 22%

Procedure

N-(4-bromo-3-methyl-5-isoxazolyl)thiophene-3-sulfonamide was prepared in the same manner as described in Example 2 from thiophene-3-sulfonyl chloride with 5-amino-4-bromo-3-methylisoxazole in 22% yield. Purification by column chromatography using 10% MeOH/CHCl3 as eluent gave a pale brown oil.

Workup

  1. customPurification by column chromatography
  2. customgave a pale brown oil

Sources & evidence

ORD record
ord-eebaf083d7874d67abaa94430aa5ea9f
Source dataset
uspto-grants-1999_10
Patent number
US05962490

Reaction notes

Loading…