Sulfuryl chloride → HCID 86754581, compound

HRID 1738565Notes

Reaction equation

[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13](N2C=CC=C2)(=[O:15])=[O:14])=[CH:4][CH:3]=1.[K].[S:24]([Cl:28])([Cl:27])(=[O:26])=[O:25]>>[CH3:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:13]([Cl:27])(=[O:15])=[O:14])=[CH:4][CH:3]=1.[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][CH2:7][C:8]2[S:9][CH:10]=[CH:11][C:12]=2[S:24]([Cl:28])(=[O:26])=[O:25])=[CH:21][CH:22]=1

Participants

Reactant 3

HCID 24648Sulfuryl chloride

HCID 5462222Potassium

HCID 54482334HCID 54482334, compound

Product 1

HCID 86754581HCID 86754581, compoundYield 51%

Procedure

2-[(4-methyl)phenethyl]thiophene-3-sulfonylchloride 2-[(4-methyl)phenethyl]thiophene-3-sulfonylchloride was prepared, as described in Example 64E, using N-{2-[(4-methyl)phenethyl]thiophene-3-sulfonyl}pyrrole by basic hydrolysis (KOH/ethanol) of the sulfonamide to this potassium salt followed by conversion of salt to the corresponding sulfonyl chloride in 51% yield.

Sources & evidence

ORD record: ord-6270a7cb30ed444db010b12035048706
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05962490

Reaction notes

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