Water → Octahydro-2H-azonin-2-one

Temperature

130 °C

Polyphosphoric acid (31.9 g) and water (3.75 g) were placed in a 100 mL round bottom flask equipped with a stir bar and a cold water condenser. The mixture was heated to 130 degrees C., and cyclooctanone oxime hydrochloride (5.9 g, 35 mmol, 1.0 eq) was added in small portions over 10 min. The oxime dissolved readily. The reaction mixture was stirred at 130 degrees C. for 1 hour, turned dark, was cooled to 100 degrees C., and poured into 100 mL of ice water. The aqueous mixture was extracted with chloroform (3×75 mL). The combined organic layers were dried over Na2SO4 and concentrated in vacuo. The 2-azacyclononanone slowly crystallized into an off-white solid (4.69 g, 94%).

1. customequipped with a stir bar and a cold water condenser
2. temperaturewas cooled to 100 degrees C
3. extractionThe aqueous mixture was extracted with chloroform (3×75 mL)
4. dry with materialThe combined organic layers were dried over Na2SO4
5. concentrationconcentrated in vacuo
6. customThe 2-azacyclononanone slowly crystallized into an off-white solid (4.69 g, 94%)

ORD record

ord-24f56bc6472c4fd7971cdf1b3454b06a

Source dataset

uspto-grants-1999_10

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05962710