10-deacetylbaccatin III → HCID 86754576, compound

Participants

Reaction Steps

A suspension of 10-deacetylbaccatin III (544 mg, 1 mmol) in a tetrahydrofuran/methyl iodide mixture (3/2, 5 ml) is added dropwise to a suspension of potassium t-butoxide (336 mg, 3 mmol, 3 equiv.) in tetrahydrofuran (4 ml) at -30° C. The mixture is then allowed to return gradually to room temperature. After stirring for 3 h 30, HPLC analysis indicates that the reaction mixture contains 10.0% (by internal standardization of the areas) of 7,10-dimethoxy-10-deacetylbaccatin.

Provenance & Evidence