Proton sponge → HCID 86754580, compound

Participants

Reaction Steps

1,8-bis(dimethylamino)naphthalene (514 mg, 2.4 mmol, 12 equiv.), 4 Å molecular sieves (700 mg) and trimethyloxonium tetrafluoroborate (296 mg, 2 mmol, 10 equiv.) are successively added to a suspension of 10-deacetylbaccatin III (109 mg, 0.2 mmol) in dichloromethane (4 ml) at 25° C. After stirring for 24 h at room temperature, HPLC analysis indicates that the reaction mixture contains 7,10-dimethoxy-10-deacetylbaccatin in an assayed yield of 17%.

Provenance & Evidence