HCID 53809911, compound → HCID 23288669, compound

HRID 1738650Notes

Reaction equation

HRID 1738650 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([NH:14][C:15]2[CH:16]=[C:17]([CH:32]=[C:33]([O:44][CH2:45][CH2:46][O:47][C:48](=[O:56])[NH:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][N:51]=3)[C:34]=2[O:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[O:42][CH3:43])[C:18]([NH:20][CH2:21][C:22]([O:24]CC2C=CC=CC=2)=[O:23])=[O:19])(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Pd]>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([NH:14][C:15]2[CH:16]=[C:17]([CH:32]=[C:33]([O:44][CH2:45][CH2:46][O:47][C:48](=[O:56])[NH:49][C:50]3[CH:55]=[CH:54][CH:53]=[CH:52][N:51]=3)[C:34]=2[O:35][C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=2[O:42][CH3:43])[C:18]([NH:20][CH2:21][C:22]([OH:24])=[O:23])=[O:19])(=[O:12])=[O:13])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 53809911HCID 53809911, compound

Product 1

HCID 23288669HCID 23288669, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

By hydrogenating benzyl {3-(4-tert-butyl-benzenesulphonylamino)-4-(2-methoxy-phenoxy)-5-[2-(pyridin-2-ylcarbamoyl-oxy)-ethoxy]-benzoylamino}-acetate, described in Example 18, in methanol over palladium/charcoal at RT and under normal pressure there was obtained {3-(4-tert-butyl-benzenesulphonylamino)-4-(2-methoxy-phenoxy)-5-[2-(pyridin-2-ylcarbamoyl-oxy)-ethoxy]-benzoylamino}-acetic acid.

Sources & evidence

ORD record
ord-fda7095691d541738020ae2933c000d7
Source dataset
uspto-grants-1999_10
Patent number
US05962682

Reaction notes

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