反应详情

Into a solution of 1.30 g of 2-fluoro-2-trifluoromethyl-4-octenamide in 13 ml of methanol, palladium-carbon (13 mg) was added under nitrogen. After the atmosphere was replaced with hydrogen, the mixture was stirred for 24 hours. To remove the catalyst, the resulting mixture was filtered with celite and the filtrate was concentrated. The raw product was purified by silica gel column chromatography to obtain 1.0 g of the desired compound.

1. customTo remove the catalyst
2. filtrationthe resulting mixture was filtered with celite
3. concentrationthe filtrate was concentrated
4. customThe raw product was purified by silica gel column chromatography