Methyl iodide → N,N-Diethyl-N-[4-hydroxy-4-methyl-8-(3-methyl-7-propyl-xanthin-1-yl)-2-octynyl]-N-methylammonium iodide

Participants

Reaction Steps

1 g (2.4 mmol) of 1-(8-diethylamino-5-hydroxy-5-methyl-6-octynyl)-3-methyl-7-propylxanthine--prepared as in Example 1A2), 1C2) or 1D2)--was introduced into 30 ml of diethyl ether, 425 mg (3.0 mmol) of methyl iodide were added, and the mixture was stirred at room temperature for 20 hours. Then a further 212 mg (1.5 mmol) of methyl iodide were added and the mixture was stirred under reflux for 2 hours. The resulting crystals were filtered off with suction, washed with diethyl ether and dried.

Provenance & Evidence