HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloroform → 1-(6-Dimethylamino-3-hydroxy-3-methyl-4-hexynyl)-3-methyl-7-propylxanthine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | N,N-Dimethylpropargylamine | HCID 81643 | — |
| Reactant | 3-Methyl-1-(3-oxobutyl)-7-propylxanthine | HCID 15390923 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | Hexane | HCID 8058 | — |
| Product | 1-(6-Dimethylamino-3-hydroxy-3-methyl-4-hexynyl)-3-methyl-7-propylxanthine | HCID 15390907 | — |
Reaction Steps
4.32 g (52 mmol) of N,N-dimethyl-2-propynylamine, 32.4 ml (52 mmol) of n-butyllithium as 1.6 M solution in n-hexane and 11.1 g (40 mmol) of 3-methyl-1-(3-oxobutyl)-7-propylxanthine were reacted in tetrahydrofuran and worked up in analogy to Example 1C2), but using chloroform in place of dichloromethane as extractant.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965555 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-3ce9ef70eda24bb09c26eb6b840e994a |
| Source note | uspto-grants-1999_10 |