Propargyl bromide → 1-Methyl-4-(prop-2-yn-1-yl)piperazine

Participants

Reaction Steps

11.1 ml (0.10 mol) of an 80% strength 2-propynyl bromide solution in toluene were added to a solution of 22.2 ml (0.20 mol) of N-methyl-piperazine in 100 ml of toluene while cooling in ice. After 30 minutes under reflux, the resulting N-methylpiperazine hydrobromide was filtered off with suction and washed with toluene, and the filtrate was washed twice each with 15% strength sodium hydroxide solution and saturated sodium chloride solution, concentrated and distilled in vacuo.

Provenance & Evidence