Dietylaminopropin → HCID 15390912, compound

HRID 1738796Notes

Reaction equation

HRID 1738796 reaction equation
[CH3:1][N:2]1[C:10]2[N:9]=[CH:8][N:7]([CH2:11][CH2:12][CH3:13])[C:6]=2[C:5](=[O:14])[N:4]([CH2:15][C:16](=[O:18])[CH3:17])[C:3]1=[O:19].[CH2:20]([N:22]([CH2:25][C:26]#[CH:27])[CH2:23][CH3:24])[CH3:21].C(O)(=O)/C=C/C(O)=O>>[CH2:20]([N:22]([CH2:23][CH3:24])[CH2:25][C:26]#[C:27][C:16]([OH:18])([CH3:17])[CH2:15][N:4]1[C:5](=[O:14])[C:6]2[N:7]([CH2:11][CH2:12][CH3:13])[CH:8]=[N:9][C:10]=2[N:2]([CH3:1])[C:3]1=[O:19])[CH3:21]

Participants

4

Reactant 3

HCID 20010DietylaminopropinHCID 444972Fumaric AcidHCID 15390924HCID 15390924, compound

Product 1

HCID 15390912HCID 15390912, compoundYield 48%

Procedure

1-(5-Diethylamino-2-hydroxy-2-methyl-3-pentynyl)-3-methyl-7-propylxanthine was prepared as oily substance in 48% yield using 3-methyl-1-(2-oxopropyl)-7-propylxanthine and N,N-diethyl-2-propynylamine as in Example 6C1). Salt formation with fumaric acid as in Example 7F2) took place in 98% yield. Melting point: 109° C. C23H33N5O7 (MW=491.56 g/mol), base C19H29N5O3 (MW=375.48 g/mol)

Sources & evidence

ORD record
ord-52ad099d4202428a8dc01535096fa6f5
Source dataset
uspto-grants-1999_10
Patent number
US05965555

Reaction notes

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