Indan-5-amine → HCID 21839590, compound

HRID 1738827Notes

Reaction equation

HRID 1738827 reaction equation
C1C2C(=CC(S[C:11]3[C:12]4[CH:20]=[CH:19][CH:18]=[N:17][C:13]=4[N:14]=[CH:15][N:16]=3)=CC=2)CC1.[NH2:21][C:22]1[CH:23]=[C:24]2[C:28](=[CH:29][CH:30]=1)[CH2:27][CH2:26][CH2:25]2>O>[CH2:27]1[C:28]2[C:24](=[CH:23][C:22]([NH:21][C:11]3[C:12]4[CH:20]=[CH:19][CH:18]=[N:17][C:13]=4[N:14]=[CH:15][N:16]=3)=[CH:30][CH:29]=2)[CH2:25][CH2:26]1

Participants

4

Reactant 2

HCID 90496Indan-5-amineHCID 21839576HCID 21839576, compound

Product 1

HCID 21839590HCID 21839590, compoundYield 40%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
130 °C

Procedure

A suspension of 4-(5-indanylthio)-pyrido[2,3-d]pyrimidine (2.79 g, 10 mM) and 5-aminoindan (3.996 g, 30 mM) in water (100 ml) is heated in a sealed tube at 130° C. for 20 h. Then the water is evaporated under vacuum and the residue chromatographed on silica gel by using dichloromethane/methanol mixtures as eluant. Thus almost pure title compound is obtained in about 40% yield.

Workup

  1. customThen the water is evaporated under vacuum
  2. customthe residue chromatographed on silica gel

Sources & evidence

ORD record
ord-1e9239a3eee9457486adc712a97de27b
Source dataset
uspto-grants-1999_10
Patent number
US05965563

Reaction notes

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