2-Naphthalenesulfonyl chloride → HCID 22721933, compound

HRID 1738837Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].Cl.Cl.[NH2:17][CH:18]([CH2:24][NH:25][C:26]([CH:28]1[CH2:33][CH2:32][N:31]([C:34]2[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=2)[CH2:30][CH2:29]1)=[O:27])[C:19]([O:21][CH2:22][CH3:23])=[O:20]>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:17][CH:18]([CH2:24][NH:25][C:26]([CH:28]1[CH2:29][CH2:30][N:31]([C:34]2[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=2)[CH2:32][CH2:33]1)=[O:27])[C:19]([O:21][CH2:22][CH3:23])=[O:20])(=[O:13])=[O:12]

Participants

Reactant 2

HCID 71252-Naphthalenesulfonyl chloride

HCID 22721877HCID 22721877, compound

Product 1

HCID 22721933HCID 22721933, compoundYield 37%

Procedure

Using an analogous procedure to that described in Example 2, 2-naphthylsulphonyl chloride was reacted with ethyl 2-amino-3-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]propionate dihydrochloride salt to give ethyl 2-(2-naphthalenesulphonamido)-3- [1-(4-pyridyl)piperidin-4-ylcarbonylamino]propionate as a foam in 37% yield;

Sources & evidence

ORD record: ord-85d0e31c8f244ecc8de97986e00bf6c3
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05965559

Reaction notes

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