1-(4-Pyridinyl)-4-piperidinecarbonyl chloride → HCID 22721895, compound

HRID 1738846Notes

Reaction equation

HRID 1738846 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([N:7]2[CH2:12][CH2:11][CH:10]([C:13](Cl)=[O:14])[CH2:9][CH2:8]2)=[CH:3][CH:2]=1.Cl.[NH:17]1[CH2:22][CH2:21][CH:20]([NH:23][S:24]([C:27]2[CH:36]=[CH:35][C:34]3[C:29](=[CH:30][CH:31]=[CH:32][CH:33]=3)[CH:28]=2)(=[O:26])=[O:25])[CH2:19][CH2:18]1>>[CH:28]1[C:29]2[C:34](=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:35]=[CH:36][C:27]=1[S:24]([NH:23][CH:20]1[CH2:21][CH2:22][N:17]([C:13]([CH:10]2[CH2:11][CH2:12][N:7]([C:4]3[CH:5]=[CH:6][N:1]=[CH:2][CH:3]=3)[CH2:8][CH2:9]2)=[O:14])[CH2:18][CH2:19]1)(=[O:26])=[O:25]

Participants

3

Reactant 2

HCID 111837001-(4-Pyridinyl)-4-piperidinecarbonyl chlorideHCID 22721849HCID 22721849, compound

Product 1

HCID 22721895HCID 22721895, compoundYield 28%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride was reacted with N-(piperidin-4-yl)naphthalene-2-sulphonamide hydrochloride salt to give 4-(2-naphthalenesulphonamido)-1-[-1-(4-pyridyl)piperidin-4-ylcarbonyl]piperidine in 28% yield;

Sources & evidence

ORD record
ord-6e05f929333c4eb6a784526de2a5573d
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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