2-Naphthalenesulfonyl chloride → HCID 22721835, compound

HRID 1738847Notes

Reaction equation

HRID 1738847 reaction equation
Cl.[NH2:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH2:4]1.[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[S:32](Cl)(=[O:34])=[O:33]>>[CH:22]1[C:31]2[C:26](=[CH:27][CH:28]=[CH:29][CH:30]=2)[CH:25]=[CH:24][C:23]=1[S:32]([NH:2][CH:3]1[CH2:7][CH2:6][N:5]([C:8]([CH:10]2[CH2:15][CH2:14][N:13]([C:16]3[CH:21]=[CH:20][N:19]=[CH:18][CH:17]=3)[CH2:12][CH2:11]2)=[O:9])[CH2:4]1)(=[O:33])=[O:34]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 22721764HCID 22721764, compound

Product 1

HCID 22721835HCID 22721835, compoundYield 37%

Procedure

Using an analogous procedure to that described in Example 2, 3-amino-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]pyrrolidine hydrochloride salt was reacted with 2-naphthylsulphonyl chloride to give 3-(2-naphthalenesulphonamido)-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]pyrrolidine in 37% yield;

Sources & evidence

ORD record
ord-dfecdb4388454b598e6b5b1188aea50e
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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