2-Naphthalenesulfonyl chloride → HCID 22721848, compound

HRID 1738849Notes

Reaction equation

HRID 1738849 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11](Cl)(=[O:13])=[O:12].[CH2:15]([O:17][C:18]([CH:20]1[NH:25][CH2:24][CH2:23][N:22]([C:26]([CH:28]2[CH2:33][CH2:32][N:31]([C:34]3[CH:39]=[CH:38][N:37]=[CH:36][CH:35]=3)[CH2:30][CH2:29]2)=[O:27])[CH2:21]1)=[O:19])[CH3:16]>>[CH2:15]([O:17][C:18]([CH:20]1[CH2:21][N:22]([C:26]([CH:28]2[CH2:33][CH2:32][N:31]([C:34]3[CH:35]=[CH:36][N:37]=[CH:38][CH:39]=3)[CH2:30][CH2:29]2)=[O:27])[CH2:23][CH2:24][N:25]1[S:11]([C:2]1[CH:3]=[CH:4][C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:1]=1)(=[O:13])=[O:12])=[O:19])[CH3:16]

Participants

3

Reactant 2

HCID 71252-Naphthalenesulfonyl chlorideHCID 22721907HCID 22721907, compound

Product 1

HCID 22721848HCID 22721848, compoundYield 31%

Procedure

Using an analogous procedure to that described in Example 2, 2-naphthylsulphonyl chloride was reacted with 3-ethoxycarbonyl-1-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine to give 2-ethoxycarbonyl-1-(2-naphthylsulphonyl)-4-[1-(4-pyridyl)piperidin-4-ylcarbonyl]piperazine in 31% yield;

Sources & evidence

ORD record
ord-6a800c51c4f24cde982349bc0b4f504b
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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