HCID 22721905, compound → HCID 22721827, compound

HRID 1738851Notes

Reaction equation

HRID 1738851 reaction equation
Cl.[N:2]1[CH:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][CH:11]([C:14](Cl)=[O:15])[CH2:10][CH2:9]2)=[CH:4][CH:3]=1.Cl.[NH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:38])[CH2:23][NH:24][S:25]([C:28]1[CH:37]=[CH:36][C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:29]=1)(=[O:27])=[O:26]>>[CH:29]1[C:30]2[C:35](=[CH:34][CH:33]=[CH:32][CH:31]=2)[CH:36]=[CH:37][C:28]=1[S:25]([NH:24][CH2:23][C:22]([NH:21][CH2:20][CH2:19][NH:18][C:14]([CH:11]1[CH2:12][CH2:13][N:8]([C:5]2[CH:6]=[CH:7][N:2]=[CH:3][CH:4]=2)[CH2:9][CH2:10]1)=[O:15])=[O:38])(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 22721905HCID 22721905, compoundHCID 22721947HCID 22721947, compound

Product 1

HCID 22721827HCID 22721827, compoundYield 49%

Procedure

Using an analogous procedure to that described in Example 1, 1-(4-pyridyl)piperidine-4-carbonyl chloride hydrochloride salt was reacted with N-(2-aminoethyl)-2-(2-naphthalenesulphonamido)acetamide hydrochloride salt to give 2-(2-naphthalenesulphonamido)-N-{2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]ethyl}acetamide in 49% yield, m.p. 107-109° C.;

Sources & evidence

ORD record
ord-ef41c75ce3894798acc3560d5e09b8db
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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