Morpholine → HCID 9189358, compound

HRID 1738864Notes

Reaction equation

[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH2:15][C:16]([NH:18]C(CNC(C1CCN(C2C=CN=CC=2)CC1)=O)C(O)=O)=[O:17])(=[O:13])=[O:12].N1CCOCC1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([NH:14][CH2:15][C:16]([NH2:18])=[O:17])(=[O:12])=[O:13]

Participants

Reactant 2

HCID 8083Morpholine

HCID 22721821HCID 22721821, compound

Product 1

HCID 9189358HCID 9189358, compoundYield 36%

Procedure

Using an analogous procedure to that described in Example 20, 2-[2-(2-naphthalenesulphonamido)acetamido]-3-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]propionic acid was reacted with morpholine to give yl-morpholinocarbonyl-2-[1-(4-pyridyl)piperidin-4-ylcarbonylamino]-ethyl}-2-(2-naphthalenesulphonamido)acetamide in 36% yield.

Sources & evidence

ORD record: ord-ffcecc499b5341fc90d38d248e63199c
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05965559

Reaction notes

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