tert-Butyl piperazine-1-carboxylate → 1-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochloride

HRID 1738874Notes

Reaction equation

HRID 1738874 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]1)=O)(C)(C)C.[Cl:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([S:25](Cl)(=[O:27])=[O:26])[CH:19]=[CH:18]2>>[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([S:25]([N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1)(=[O:27])=[O:26])[CH:19]=[CH:18]2

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 106351296-Chloronaphthalene-2-sulfonyl chloride

Product 1

HCID 227097661-(6-Chloronaphth-2-ylsulphonyl)piperazine hydrochlorideYield 58%

Procedure

Using analogous procedures to those described in two of the paragraphs of the portion of Example 50 which is concerned with the preparation of starting materials, 1-tert-butoxycarbonylpiperazine was reacted with 6-chloronaphth-2-ylsulphonyl chloride to give 1-(6 -chloronaphth-2-ylsulphonyl)piperazine hydrochloride salt in 58% yield.

Sources & evidence

ORD record
ord-49d7dab6f4764a33991ad53e64f518af
Source dataset
uspto-grants-1999_10
Patent number
US05965559

Reaction notes

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