Dichloromethane → HCID 21839655, compound

Participants

Reaction Steps

This reaction was performed in a manner similar to that described for the preparation of IIc, starting from mesylate IV (X=--CH2 --; R=n--C4H9) (13.6 g, 47.2 mmol), silica gel (14 g) and dichloromethane (140 ml). The residue obtained was subjected to column chromatography on silica gel (120 g) using hexane/ethyl acetate mixtures of increasing polarity as eluent. On elution with 95:5 hexane/ethyl acetate, the ketone IIe (3.7 g, 41% yield) was obtained. Continuing the elution with 90:10 hexane/ethyl acetate, alcohol V (X=--CH2 --; R=n--C4H9) (2.8 g, 28% yield) was obtained.

Provenance & Evidence