Ethyl Acetate → HCID 70345096, compound

Participants

Reaction Conditions

Reaction Steps

Trans-7-chloro-5-(1 -naphthyl)-1 -(4-iodobutyl)-2-oxo-1,2,3,5-tetrahydro-4,1 -benzoxazepine-3-acetonitrile (575 mg, 1.06 mmol), 2-methylimidazole (87 mg, 1.06 mmol) and potassium carbonate (146 mg, 1.06 mmol) were dissolved in DMF (5 ml) and the resulting solution stirred at 25° C. for 72 hours. Ethyl acetate was added and the solution washed with water (4×). The organic layer was dried (MgSO4), concentrated under reduced pressure and purified by flash column chromatography (ethyl acetate/diethylamine 95:5) to give the title compound (250 mg, 47%) as a colorless foam.

Provenance & Evidence