反应详情

A solution of 3-(3,4-dichlorophenyl)-3-(2-propyl-3-oxo-2,3-dihydro-1H-isoindol-1-yl)propionaldehyde (0.235 g) was treated with 4-(2-methylsulfinylphenyl)piperidine (0.236 g) as described in Example 8. The resulting material was purified by chromatography and was transformed into the hydrochloride to afford the title compound (0.09 g); mp 78-85° C. (dec); MS: m/z=583(M+1); NMR(CD3OD): 0.92 (m,3), 1.5-4.3 (m,21), 4.98-5.04 (m,1), 7.27 (m,1l). Analysis for C32H36Cl2N2O2S.1.0 HCl.0.5 H2O: Calculated: C, 61.09; H, 6.08; N, 4.45; Found: C, 60.78; H, 5.68; N, 4.67.

1. customThe resulting material was purified by chromatography