HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → HCID 54112731, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | diethyl ((1-(triphenylmethyl)-1H-imidazol-4-yl)methyl)phosphonate | HCID 2763175 | — |
| Reactant | HCID 21840013 | HCID 21840013 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 54112731 | HCID 54112731 | — |
Reaction Conditions
| Temperature | -78 °C |
|---|
Reaction Steps
The product from Step H is dissolved in THF and cooled to -78° C. under nitrogen. A solution of LDA in THF is added dropwise. The reaction is stirred at -78° C. for 1 h, then a solution of 4-formyl-1-phenyl-2-piperidinone from Step E is added, and the reaction warmed to room temperature overnight. The reaction is quenched with ammonium chloride solution, and extracted with ethyl acetate. The title compound is obtained after chromatography on silica gel
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965578 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-987f982a24e1473386f854ce52af3a4a |
| Source note | uspto-grants-1999_10 |