Thiazolidinedione → HCID 86754590, compound

HRID 1739013Notes

Reaction equation

[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20](/[CH:25]=[CH:26]/[CH:27]=O)[CH:19]=[CH:18]2.[S:29]1[CH2:33][C:32](=[O:34])[NH:31][C:30]1=[O:35]>>[CH3:1][C:2]1[O:6][C:5]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)=[N:4][C:3]=1[CH2:13][O:14][C:15]1[CH:16]=[C:17]2[C:22](=[CH:23][CH:24]=1)[CH:21]=[C:20]([CH:25]=[CH:26][CH:27]=[C:33]1[S:29][C:30](=[O:35])[NH:31][C:32]1=[O:34])[CH:19]=[CH:18]2

Participants

Reactant 2

HCID 5437Thiazolidinedione

HCID 21840317HCID 21840317, compound

Product 1

HCID 86754590HCID 86754590, compoundYield 73%

Procedure

According to the same manner as that described in Example 1, (E)-3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-naphthyl]acrolein was condensed with 2,4-thiazolidinedione to give 5-[3-[6-(5-methyl-2-phenyl-4-oxazolylmethoxy)-2-naphthyl]propenylidene]-2,4-thiazolidinedione (yield: 73%). This product was recrystallized from chloroform-methanol. Yellow prisms, mp: 267-268° C.

Sources & evidence

ORD record: ord-151775a89e9b48c1adf04859da61d008
Source dataset: uspto-grants-1999_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05965589

Reaction notes

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