HCID 86754594, compound → HCID 86754593, compound

Participants

Reaction Steps

A mixture of 5-[3-[3-methoxy-4-[2-[(E)-2-phenylethenyl]-4-oxazolylmethoxy]phenyl]propyl]-2,4-thiazolidinedione (0.37 g), palladium-carbon (5%, 0.74 g) and tetrahydrofuran (20 ml) was subjected to catalytic hydrogenation at 1 atm and room temperature. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give crystals. The crystals were recrystallized from ethyl acetate-hexane to give 5-[3-[3-methoxy-4-(2-phenethyl-4-oxazolylmethoxy)phenyl]propyl]-2,4-thiazolidinedione (0.20 g, 54%). Colorless prisms, mp: 126-127° C.

Provenance & Evidence