HCID 15453974, compound → HCID 18696217, compound

HRID 1739062Notes

Reaction equation

HRID 1739062 reaction equation
C(OC([NH:8][CH2:9][CH2:10][S:11][C:12]1[C:16]2[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1)=O)(C)(C)C.[ClH:22].O1CCOCC1>O1CCOCC1>[ClH:22].[NH2:8][CH2:9][CH2:10][S:11][C:12]1[C:16]2[CH:17]=[C:18]([F:21])[CH:19]=[CH:20][C:15]=2[O:14][N:13]=1

Participants

4

Reactant 2

HCID 15453974HCID 15453974, compoundHCID 204431481,4-Dioxane hydrochloride

Product 1

HCID 18696217HCID 18696217, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
5 °C

Procedure

To a solution of 3-(2-(N-t-butoxycarbonylamino)ethylthio)-5-fluoro-1,2-benzisoxazole (0.20 g) in dioxane (2 ml) was added 4N-hydrochloric acid/dioxane solution (0.8 ml) with stirring at 5° C., and the mixture was then stirred at room temperature for 30 minutes. After completion of the reaction, the solvent was evaporated under reduced pressure and the residue was recrystallized from ethanol and ethyl acetate, to give the title compound (0.14 g) as a colorless needle.

Workup

  1. stirringthe mixture was then stirred at room temperature for 30 minutes
  2. customAfter completion of the reaction
  3. customthe solvent was evaporated under reduced pressure
  4. customthe residue was recrystallized from ethanol and ethyl acetate

Sources & evidence

ORD record
ord-3413663fe182451f95762bcfe2102829
Source dataset
uspto-grants-1999_10
Patent number
US05965591

Reaction notes

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