4'-Formyl-[1,1'-biphenyl]-2-carbonitrile → HCID 66577501, compound

Participants

Reaction Steps

Reaction of 2.0 g of 2'-cyanobiphenyl-4-carbaldehyde, 9.6 g of molecular sieve 5 A, 1.34 g of (D)-alanine methyl ester hydrochloride and 680 mg of sodium cyanoborohydride yields N-[(2'-cyanobiphenyl-4-yl)methyl]-(D)-alanine methyl ester after flash chromatography (N3). 1H-NMR (DMSO): 1.21 ppm (d, 3 H), 3.63 ppm (s, 3 H), 3.75 ppm (dd, 1 H), 4.56 ppm (d, 2 H), 4.58 ppm (d, 2 H), 5.31 ppm (t, 1 H), 7.4-8 ppm aromatics.

Provenance & Evidence