4'-Formyl-[1,1'-biphenyl]-2-carbonitrile → HCID 53822382, compound

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Reaction Steps

The reaction of 2.0 g of 2'-cyanobiphenyl-4-carbaldehyde, 9.6 g of molecular sieve 5 A, 1.34 g of (L)-norvaline methyl ester hydrochloride and 680 mg of sodium cyanoborohydride yields N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-norvaline methyl ester after flash chromatography (N3). 1H-NMR (DMSO): 0.83 ppm (t, 3 H), 1.33 ppm (m, 2 H), 1.55 ppm (m, 2 H), 3.62 ppm (s, 3 H), 3.1 ppm (m, 1 H), 7.3-8 ppm aromatics.

Provenance & Evidence