HuagongsheHuagongshe Chemistry Print Report · For research reference only
Valeryl chloride → N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-N-(1-oxopentyl)-L-valine methyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Valeryl chloride | HCID 61186 | — |
| Reactant | N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-L-valine methyl ester | HCID 16744794 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | N-((2'-Cyano(1,1'-biphenyl)-4-yl)methyl)-N-(1-oxopentyl)-L-valine methyl ester | HCID 16744795 | — |
Reaction Steps
Reaction of 1.15 g of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester, 0.625 ml of triethylamine and 0.56 ml of n-valeryl chloride analogously to Example 1c) yields N-valeryl-N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine methyl ester after flash chromatography (N3). (TLC: N2) Rf : 0.63.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965592 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-9f3cb233c5a14d40aa9abf732cb900d6 |
| Source note | uspto-grants-1999_10 |