HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-[N-(3-Benzyloxypropyl)aminomethyl]-2'-cyanobiphenyl
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 4'-(Bromomethyl)-2-cyanobiphenyl | HCID 1501912 | — |
| Reactant | 3-(benzyloxy)propan-1-amine | HCID 7130784 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-[N-(3-Benzyloxypropyl)aminomethyl]-2'-cyanobiphenyl | HCID 21840405 | — |
Reaction Steps
A solution of 6.0 g (22 mmol) of 4-bromomethyl-2'-cyanobiphenyl, 5.8 g (35 mmol) of 3-benzyloxypropylamine (Synthesis 1975, 590) and 3.6 g of triethylamine in 50 ml of 1,4-dioxane is heated to boiling under reflux for 18 hours. After working up analogously to Example 23 a), an oil is obtained which, after flash-chromatographic purification (ethanol:ethyl acetate: 1:4), gives the title compound (TLC system B7; Rf value 0.39).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05965592 |
| Source dataset | uspto-grants-1999_10 |
| ORD ID | ord-58863080f7f94a5aac2b051e30045602 |
| Source note | uspto-grants-1999_10 |