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HRID1739082

反应详情

EQUATION

反应方程式

HRID 1739082 的结构方程式

REACTANTS

反应物

2
结构：CCCCC(=O)Cl
HCID61186

Valeryl chloride

C5H9ClO

结构：CC(C)[C@H](NCc1ccc(-c2ccccc2C#N)cc1)C(=O)OCc1ccccc1
HCID11112111

N-[(2′-Cyano[1,1′-biphenyl]-4-yl)methyl]-L-valine phenylmethyl ester

C26H26N2O2

PRODUCTS

生成物

1
结构：CCCCC(=O)N(Cc1ccc(-c2ccccc2C#N)cc1)[C@H](C(=O)OCc1ccccc1)C(C)C
HCID46912012

Benzyl N-[(2'-cyano[1,1'-biphenyl]-4-yl)methyl]-N-pentanoyl-L-valinate

C31H34N2O3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCl
溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

6.2 g (15.5 mmol) of N-[(2'-cyanobiphenyl-4-yl)methyl]-(L)-valine benzyl ester and 8.0 ml of Huinig base, dissolved in 50 ml of methylene chloride, are treated with 2.3 ml of valeryl chloride with stirring and further processed analogously to Example 29b. The title compound is thus obtained as a yellow oil which is further used in crude form (Rf 0.51, toluene-methanol 19:1)