Hydrochloric Acid → HCID 178447301, compound

Participants

Reaction Steps

A solution of 91 g (about 100 mmol) of crude N-[(2'-(1-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-(L)-valine benzyl ester in 300 ml of dioxane is treated at 60° with 300 ml of 1N hydrochloric acid and kept at 60° for 2 hours. The dioxane is then evaporated in vacuo and the aqueous phase is rendered alkaline with 2N potassium hydroxide solution. Neutral portions are extracted with ether. The aqueous phase gives the crude title compound as an oil (Rf 0.40 in system A2) by acidifying and extracting with ethyl acetate.

Provenance & Evidence