Benzylamine → HCID 178447285, compound

HRID 1739088Notes

Reaction equation

HRID 1739088 reaction equation
[NH:1]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH2:26][C:27]3([C:32]([OH:34])=[O:33])[CH2:31][CH2:30][CH2:29][CH2:28]3)[C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=2)=[N:4][N:3]=[N:2]1.C(N)C1C=CC=CC=1>>[CH2:5]([NH2:1])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:4]1[C:5]([C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[C:12]2[CH:17]=[CH:16][C:15]([CH2:18][N:19]([CH2:26][C:27]3([C:32]([OH:34])=[O:33])[CH2:28][CH2:29][CH2:30][CH2:31]3)[C:20](=[O:25])[CH2:21][CH2:22][CH2:23][CH3:24])=[CH:14][CH:13]=2)=[N:1][N:2]=[N:3]1

Participants

3

Reactant 2

HCID 7504BenzylamineHCID 178447284HCID 178447284, compound

Product 1

HCID 178447285HCID 178447285, compound

Procedure

0.507 g of N-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-N-valeryl-1-aminomethylcyclopentane-1-carboxylic acid is reacted with 0.214 g of benzylamine analogously to Example 48 and the rude product is purified on silica gel 60 (40-63 μm) using CH2Cl2 --MeOH 95:5, Rf =0.49 (system N8). MS (FAB): m /e 551 (M+ +H), 573 (M+ +Na).

Workup

  1. customthe rude product is purified on silica gel 60 (40-63 μm)

Sources & evidence

ORD record
ord-e71e4f2f395a4e71846b943b9a58595d
Source dataset
uspto-grants-1999_10
Patent number
US05965592

Reaction notes

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