Reaction Steps
This compound was prepared using the same method as for the preparation of methionine derivative (See Example 26, section B), using 4-amino-2-phenylbenzoyl-(S)-leucine methyl ester and N-Boc-S-trityl-(L)-cysteinal as starting materials. 1H NMR (CDCl3) δ 7.68 (d, 8.6 Hz, 1H), 7.33-7.41 (m, 11H), 7.17-7.29 (m, 9H), 6.50 (d, 8.6 Hz, 1H), 6.31 (s, 1H), 5.43 (d, 7.8 Hz, 1H), 4.60 (d, 6.1 Hz, 1H), 4.47 (ddd, 1H), 4.19 (br t, 1H), 3.77 (br m, 1H), 3.62 (s, 3H), 3.09 (t, 5.9 Hz, 2H), 2.45 (br m, 2H), 1.40 (s, 9H), 1.27-1.33 (m, 1H), 1.03-1.18 (m, 2H), 0.75 (dd, 6H); 13C (CDCl3) δ 173.2, 168.2, 155.6, 149.4, 144.4, 141.7, 141.2, 131.4, 129.5, 128.8, 128.5, 127.9, 127.6, 126.8, 122.7, 113.6, 111.3, 79.6, 67.1, 51.9, 50.9, 49.5, 47.1, 41.2, 34.3, 28.3, 24.4, 22.7, 21.8.
