Hydrochloric Acid → HCID 21840616, compound

Participants

Reaction Steps

5-fluoro-2-methyl-3-indenylacetic acid (15 g, 0.072 mol), p-methoxybenzaldehyde (12.39 g, 0.091 mol) and sodium methoxide (13.0 g, 0.24 mol) are heated in methanol (200 ml) at 60° C. under nitrogen with stirring for 6 hours. After cooling, the reaction mixture is poured into 750 ml of ice-water, and is acidified with 2.5 N hydrochloric acid. The collected solid is triturated with a little ether to produce (Z)-5-fluoro-2-methyl-1-(-methoxybenzylidene)-3-indenylacetic acid (m.p. 184-186° C.).

Provenance & Evidence